Khandu, born in Gyangkhar village in Arunachal was a former army intelligence officer rewarded for his exploits during the Bangladesh war and had turned a social activist before joining politics in 1980.
The other political activities which he served are :
•1983 – 87 : Elected uncontested as District Vice President, West Kameng district Zilla Parishad 1983 – 87.
•1987 – 1990 : Engaged in Intensive Social Works and Brought Water Supply, Electricity, Communication, Schools Religious Institutions etc., to far flung villagers from 1987 to 1990.
•1990 : Elected uncontested to the First Legislative Assembly of the State of Arunachal Pradesh in March, 1990 from Thingbu – Mukto constituency.
•1995 : Re – elected to Second Legislative Assembly of the State of Arunachal Pradesh in March, 1995 from the same constituency. Minister of State for Cooperation from 21.03.1995.
•1996 : Cabinet Minister for Animal Husbandry & Veterinary, Dairy Development from 21 September, 1996.
•1998 : Minister, Power from 2006 – 1998.
•1999 : Elected to Third Legislative Assembly of the State of Arunachal Pradesh in October, 1999.
•2002 : Minister for Mines, Relief & Rehabilitation from 15 October, 2002 to 27 July, 2003.
•2003 : Minister for Relief & Rehabilitation and Disaster Management.
•2004 : Re – elected unopposed from Mukto constituency in 2004 assembly election; Minister, Power, NCER, and relief and rehabilitation